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8,021 pcs
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8021 pcs | On Request | 1 | On Request | On Request | 1240+ | On Request | On Request |
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The PF-543 hydrochloride, identified by catalog number S7177, is a selective inhibitor of Sphingosine Kinase 1 (SphK1). It functions as a competitive inhibitor with reported IC50 and Ki values of 2.0 nM and 3.6 nM, respectively, demonstrating over 100-fold selectivity against the SphK2 isoform.
This compound is known to induce apoptosis, necrosis, and autophagy. It has a molecular weight of 502.07 g/mol and a typical purity of 99.52%. The product has been cited in Nature Medicine for its quality.
Reported activity includes antiproliferative effects against PC3 cells with a GI50 of 19 μM after 72 hours. In other assays, it shows inhibition with IC50 values of 0.0008 μM in MDA1483 cells and 0.002 μM in Sf9 cells, and a Ki of 0.0036 μM in Sf21 cells.
| Qty | Low | High |
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| 1+ | $0.99 | $0.99 |
Estimated market price range - modelled values for guidance only, not live distributor offers.
The typical inhibition IC50 for PF-543 hydrochloride against SphK1 is 2.0 nM.
PF-543 hydrochloride exhibits greater than 100-fold selectivity for SphK1 compared to SphK2.
The molecular weight of PF-543 hydrochloride is 502.07 g/mol.
The typical purity of PF-543 hydrochloride is 99.52%.
PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
The antiproliferative activity against PC3 cells after 72 hours is a GI50 of 19 μM.